12. Other Possible Pathophysiology

Other Possible Pathophysiology

  • Antibody binding a functional site on vWF
  • Adsorption to tumor cells (prostate CA)
    • vWF noted within tumor cells in some reports
    • removal of tumor curative in some cases
  • Increased proteolytic degradation of vWF by drugs (not in this patient)

Disorders associated with acquired vWD

  • Monoclonal gammopathy 42%
    • MGUS
    • myeloma
  • B-cell Lymphoproliferative disorders 15%
    • non-Hodgkin's lymphoma
    • CLL
  • Myeloproliferative disorders 10%
  • Wilms tumor, Adrenocortical CA 8-10 %
  • Drugs (Valproic acid, Cipro) 7%
  • Hypothyroidism 5%
  • Aortic stenosis
    Angiodysplasia }<10%
    Unknown