Edward Leonard Snyder MD
Professor of Laboratory Medicine; Associate Chair, Clinical Affairs (Therapeutic); Director, Apheresis/Transfusion Service; Director, Blood Bank; Director of Membership, Yale Cancer Center; Editor, Lab News
Cytoskeleton; Health and Medicine; Membranes; Metabolism; Apheresis Technology; Pathogen Inactivation; Platelet Apoptosis; Platelet Storage Lesion Manufacturing Tissue Engineered Vascular Grafts for Pediatric Surgical Patients
Dr. Snyder's research relates to the broad field of Transfusion Medicine and, more specifically, Transfusion Oncology and Transfusion Immunobiology. His current research includes an on-going evaluation of the platelet storage lesion. This includes evaluation of alterations that occur in platelet metabolism during various storage conditions, in the platelet's cystoskeleton and in the mitochondria within platelets. Studies of the in vitro and in vivo aspects of platelet storage are an on-going effort in the laboratory. Dr. Snyder also has a long-term history of investigating the role of leukodepletion in blood components. Most recently, the laboratory has turned to the evaluation of new pathogen reduction technology. This includes the addition of various compounds to blood to remove known and potentially dangerous, as well as unknown, viral, bacterial, and protozoal contaminants in donated blood. The laboratory has a special expertise in radiolabeling human blood cells. The laboratory is currently performing clinical trials related to in vivo recovery and survivals using indium-111 and chromium-51 radiolabeled platelets and red cells, as well as Phase III trials for transfusion of pathogen-reduced blood components into patients. We are also involved in ongoing evaluations of clinical responses of patients to pheresis interventions for a variety of immunologic disorders. This is often done in conjunction with the evaluation of new apheresis machine hardware developed by a variety of corporations.
Dr. Snyder's current research also involves the seeding of biodegradable support structures (mandrils) for use with children with congenital heart disease. This is done in conjunction with Dr. Christopher Breuer.